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J Am Coll Cardiol, 40 (1): 142–148.Sheldon, R.S., Sheldon, A.G., et al. The direction of impulses is fromdendrite to cell body to axon or from cell body to axon.Functionally, the dendrites and cell body of multipolarneurons are the receptor portions of the cell, and theirplasma membrane is specialized for impulse generation.The axon is the conducting portion of the cell, and itsplasma membrane is specialized for impulse conduction.The terminal portion of the axon, the synaptic ending,contains various neurotransmitters—that is, small mol-ecules released at the synapse that affect other neuronsas well as muscle cells and glandular epithelium. A thermostableoxidation-reduction system (Hopkins, F. The time course of change of various cytokines (IL-8, IP-10, MCP-1, MIP-1, IL-6, INR?, G-CSF, VEGF) has been reported after primary andmetastatic tumor resection. A second weakness of psychoanalysis as a frame ofreference is that it can do no more than be wise after the event

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Principles and Practice of Palliative Care and Supportive Oncology. These publishedmodels should be consulted for further detail on the approachfor applying the PBPK methodology in specific cases

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